3,5-Dibromobenzaldehyde → (3,5-Dibromophenyl)methanol

Temperature

0 °C

3,5-Dibromobenzaldehyde (1.7 g, 6.3 mmol) was dissolved in methanol (100 mL) and sodium borohydride (0.250 g, 6.3 mmol) was added at 0° C. The reaction mixture was stirred for 0.5 h at 0° C. and then at 20° C. for another 0.5 h. The reaction mixture was concentrated in vacuo, diluted with brine (250 mL), acidified with hydrochloric acid and extracted with dichloromethane (3×50 mL). Evaporation of the organic solution gave 3,5-dibromo-benzyl alcohol as a white crystalline compound.

1. waitat 20° C. for another 0.5 h
2. concentrationThe reaction mixture was concentrated in vacuo
3. additiondiluted with brine (250 mL)
4. extractionextracted with dichloromethane (3×50 mL)
5. customEvaporation of the organic solution

ORD record

ord-4cb25c0e0f3a4d0ca4148708a40f6b8e

Source dataset

uspto-grants-2011_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07968723B2