Methyl morpholine oxide → HCID 86622962, compound

Participants

Reaction Steps

NMO (184 mg, 1.32 mmol) was added to a sol. of N-[2-(4-chloro-3-hydroxymethyl-phenyl)-ethyl]-acetamide (100 mg, 0.439 mmol) in CH2Cl2 (9.22 mL). The mixture was stirred for 30 min, and tetrapropylammonium perruthenate (15.5 mg, 0.044 mmol) was added. The mixture was stirred for 1 h at rt, and was filtered over celite. The filtrate was evaporated under reduced pressure. Purification of the crude by FC(CH2Cl2/MeOH 49:1) yielded the title compound (50 mg, 50%). LC-MS: tR=0.75 min; ES+: 267.10.

Provenance & Evidence