Trifluoroacetic acid → HCID 68157346, compound

Participants

Reaction Steps

To a solution of [(S)-1-(5-methyl-1-phenyl-1H-benzoimidazol-2-yl)ethyl]carbamic acid tertbutyl ester (912 mg, 2.59 mmol) in DCM (10 mL) was added TFA (5 mL) and the mixture was stirred at RT for 2 h. Volatiles were removed under reduced pressure and the resulting residue was dissolved in DCM (40 mL) and washed with a saturated solution of NaHCO3 (50 mL). The two phase system was stirred for 10 min, then the organic layer was dried (Na2SO4) and concentrated in vacuo affording (S)-1-(5-Methyl-1-phenyl-1H-benzoimidazol-2-yl)ethylamine (617 mg, 95%). LCMS: RT 2.10 and 2.23 min [M−NH2] 252.0.

Provenance & Evidence