HCID 67148438, compound → HCID 86632364, compound

Participants

Reaction Steps

MnO2 (10.6 g, 110 mmol) was added to a sol. of 3-(4-chloro-3-hydroxymethyl-phenyl)-N-methyl-propionamide (2.50 g, 11.0 mmol) in CH3CN (223 mL). The mixture was stirred for 1 h at rt. The mixture was filtered over celite and washed with CH3CN and CH2Cl2. The filtrate was evaporated under reduced pressure, and the residue was dried under high vacuum to yield the crude title compound (2.30 g, 93%) that was used without further purification. LC-MS: tR=0.76 min; ES+: 267.30.

Provenance & Evidence