Sodium Hydroxide → HCID 86632366, compound

Participants

Reaction Steps

{2-[3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethyl}-(2,2-difluoro-ethyl)-carbamic acid tert-butyl ester (7.50 g, 16.2 mmol) was dissolved in MeOH (323 mL). Aq. 1M NaOH (161 mL) was added, and the mixture was heated to reflux for 1 h. The solvents were partially removed under reduced pressure, and the aq. residue was diluted with water (900 mL). The mixture was extracted with Et2O (3×). The combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure to yield to crude title compound (4.60 g, 81%) that was used further without purification. LC-MS: tR=1.00 min; ES+: 317.31.

Provenance & Evidence