Phosphate → HCID 67148610, compound

Participants

Reaction Steps

Me3P (1M in toluene, 4.20 mL, 4.20 mmol) was added to a sol. of [5-(2-azido-ethyl)-2-chloro-benzyl]-cyclopropyl-carbamic acid tert-butyl ester (1.49 g, 4.25 mmol) in THF (13.0 mL), and the mixture was stirred at rt for 5 h. Phosphate buffer (pH 7.4, DPBS Gibco 14200, diluted 10×) was added, and the mixture was extracted with CH2Cl2 several times. The combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Drying the residue under high vacuum yielded the crude title compound (1.34 g, 97%) that was used further without purification. LC-MS: tR=0.81 min; ES+: 325.18.

Provenance & Evidence