3-Fluoro-2-nitro-N-phenylaniline → HCID 44254861, compound

Participants

Reaction Steps

A mixture of (3-fluoro-2-nitrophenyl)phenylamine (1.06 g, 4.56 mmol) and 10% Pd/C (100 mg) in EtOAc (20 mL) was degassed with a stream of nitrogen and stirred at RT under a hydrogen atmosphere for 7 h. The suspension was then filtered through a PTFE frit and the filtrate was concentrated in vacuo. The resulting residue was purified by column chromatography (Si—PCC, gradient 0-20% EtOAc in cyclohexane) affording 3-Fluoro-N1-phenylbenzene-1,2-diamine (440 mg, 48%). LCMS: RT 3.46 min [M+H]+ 203.1.

Provenance & Evidence