Hydrochloric Acid → HCID 67148790, compound

Participants

Reaction Conditions

Reaction Steps

HCl (4M in dioxane, 17 mL) was added to a sol. of (2-{3-[(tert-butoxycarbonyl-cyclopropyl-amino)-methyl]-4-chloro-phenyl}-ethyl)-carbamic acid methyl ester (1.73 g, 4.52 mmol) in CH2Cl2 (17 mL) at 0° C. The mixture was stirred at 0° C. for 2.5 h, and was washed with aq. 1M NaOH. The aq. layer was extracted back with CH2Cl2. The combined org. extracts were washed with brine, dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Drying the residue under high vacuum yielded the crude title compound (1.27 g, 99%) that was used further without purification. LC-MS: tR=0.64 min; ES+: 283.41.

Provenance & Evidence