HCID 86622950, compound → HCID 86622953, compound

Participants

Reaction Steps

MnO2 (3.89 g, 40.2 mmol) was added to a sol. of (4-chloro-3-hydroxymethyl-benzyl)-(2,2-difluoro-ethyl)-carbamic acid tert-butyl ester (2.71 g, 18.2 mmol) in CH3CN (85 mL) at rt. The mixture was stirred at rt for 4 h, and MnO2 (2.71 g, 18.2 mmol) was added again. The mixture was stirred overnight. The mixture was filtered over Celite, and the precipitate was washed with CH3CN and CH2Cl2. The filtrate was evaporated under reduced pressure to yield the crude title compound (2.80 g, quantitative yield) that was used further without purification. LC-MS: tR=1.03 min; ES+: not visible.

Provenance & Evidence