HCID 131728981, compound → HCID 131728980, compound

Participants

Reaction Steps

Mg (1.02 g, 41.8 mmol) was added to a sol. of compound C2 (4.70 g, 8.36 mmol) in MeOH (230 mL). The reaction mixture was stirred at rt for 2 h. Mg (1.02 g, 41.8 mmol) was added again, and the mixture was stirred for 2 h again. The reaction mixture was heated to 70° C. and stirred at this temperature for 16 h. The mixture was allowed to cool down to rt, and was quenched with aq. sat. NH4Cl (5 mL). EtOAc was added, and the mixture was washed with water (2×) and brine (1×). The org. phase was dried over MgSO4, filtered, and concentrated under reduced pressure. Purification of the crude by FC (EtOAc/heptane 5:45→6:44→7:43→8:42) yielded the title compound (595 mg, 13%). LC-MS: tR=1.18 min; ES+: 564.18.

Provenance & Evidence