Sodium Hydroxide → HCID 131728989, compound

Participants

Reaction Steps

To a sol. of compound D2 (595 mg, 1.05 mmol) in EtOH (6.00 mL) was added aq. 1M NaOH (2.0 mL), and the resulting mixture was stirred at rt for 1 h, and at 70° C. overnight. The mixture was partially concentrated under reduced pressure, and the aq. residue was acidified with aq. 2M HCl. The mixture was extracted with EtOAc. The combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Drying the residue under high vacuum yielded the crude title compound (573 mg, 98%) that was used further without purification. LC-MS: tR=1.11 min; ES+: 534.91.

Provenance & Evidence