Sodium Hydroxide → HCID 131728990, compound

Participants

Reaction Conditions

Reaction Steps

Aq. 1M NaOH (6.50 mL) was added to a sol. of compound D8 (1.19 g, 2.10 mmol) in EtOH (12 mL). The mixture was heated to 70° C. for 2 h. The mixture was allowed to cool to rt, and the solvents were partially removed under reduced pressure. The resulting mixture was partitioned between EtOAc and aq. 2M HCl. The phases were separated, and the aq. phase was extracted with EtOAc (2×). The combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Drying the residue under high vacuum yielded the crude title compound (1.07 g, 92%) that was used further without purification. LC-MS: tR=1.08 min, ES+: 551.33.

Provenance & Evidence