N-({2-chloro-5-[3-(methyloxy)propyl]phenyl}methyl)cyclopropanamine → (rac.)-(1R,5S)-7-{4-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-6-carboxylic acid [2-chloro-5-(3-methoxy-propyl)-benzyl]-cyclopropyl-amide

Participants

Role	Name	HCID	Charge
Reactant	N-({2-chloro-5-[3-(methyloxy)propyl]phenyl}methyl)cyclopropanamine	HCID 57956085	—
Reactant	(1R,5S)-7-{4-[2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3,9-di-tert-butyl ester	HCID 67149015	—
Product	(rac.)-(1R,5S)-7-{4-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-6-carboxylic acid [2-chloro-5-(3-methoxy-propyl)-benzyl]-cyclopropyl-amide	HCID 67148201	—

Reaction Steps

This compound was synthesized from (rac.)-(1R*,5S*)-7-{4-[2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3,9-di-tert-butyl ester (WO 2005/040165) and N-[2-chloro-5-(3-methoxypropyl)benzyl]cyclopropanamine, as for compound L1, and as described for Example 1. MS (ESI, Q+) m/z 697.9.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07968720B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-25cd60edf7274f4e977451fe480d722b
Source note	uspto-grants-2011_06