n-[2-Chloro-5-(2-methoxyethyl)benzyl]cyclopropanamine → (1R,5S)-7-{4-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-6-carboxylic Acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide

Participants

Role	Name	HCID	Charge
Reactant	n-[2-Chloro-5-(2-methoxyethyl)benzyl]cyclopropanamine	HCID 51350448	—
Reactant	(1R,5S)-7-{4-[2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3,9-di-tert-butyl ester	HCID 67149015	—
Product	(1R,5S)-7-{4-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-6-carboxylic Acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide	HCID 67149045	—

Reaction Steps

This compound was synthesized from (rac.)-(1R*,5S*)-7-{4-[2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3,9-di-tert-butyl ester (WO 2005/040165) and [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amine as for compound L1, and then Example 1. MS (ESI, Q+) m/z 686.0.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07968720B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-c586143a9e88422db39d951976237b09
Source note	uspto-grants-2011_06