Cyclopropyl-[2,3-dichloro-5-(3-methoxy-propyl)-benzyl]-amine → (1R,5S)-7-{4-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-6-carboxylic Acid cyclopropyl-[2,3-dichloro-5-(3-methoxy-propyl)-benzyl]-amide

Participants

Role	Name	HCID	Charge
Reactant	Cyclopropyl-[2,3-dichloro-5-(3-methoxy-propyl)-benzyl]-amine	HCID 57956067	—
Reactant	(1R,5S)-7-{4-[2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3,9-di-tert-butyl ester	HCID 67149015	—
Product	(1R,5S)-7-{4-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-6-carboxylic Acid cyclopropyl-[2,3-dichloro-5-(3-methoxy-propyl)-benzyl]-amide	HCID 67148324	—

Reaction Steps

This compound was synthesized from (1R,5S)-7-{4-[2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3,9-di-tert-butyl ester and cyclopropyl-[2,3-dichloro-5-(3-methoxy-propyl)-benzyl]-amine as for compound L1, and then Example 1. MS (ESI, Q+) m/z 733.9.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07968720B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-50ff38288a5a4316959b81c266f6f624
Source note	uspto-grants-2011_06