4-Methylmorpholine → HCID 68157210, compound

Participants

Reaction Steps

A mixture of 4-fluoro-N1-phenylbenzene-1,2-diamine (866 mg, 4.3 mmol), (S)-2-tertbutoxycarbonylaminopropionic acid (890 mg, 4.7 mmol), HOAt (640 mg, 4.7 mmol), 4-methylmorpholine (1.0 mL, 9.5 mmol) and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (900 mg, 4.7 mmol) in DCM (20 mL) was stirred at RT for 2 h. The reaction mixture was partitioned between DCM and a saturated aqueous solution of NaHCO3. The organic fraction was washed with brine, dried (MgSO4) and concentrated in vacuo to afford the title compound as a yellow-orange solid (quantitative). The crude product was used in the following step without further purification. LCMS (Method B): RT 3.83 min [M+H]+ 374.1.

Provenance & Evidence