HCID 68157224, compound → HCID 68157429, compound

Participants

Reaction Steps

A solution of {(S)-1-[2-(3-cyanophenylamino)phenylcarbamoyl]ethyl}carbamic acid tert-butyl ester (289 mg, 0.75 mmol) in AcOH (3 mL) was heated at 80° C. for 16 h. After cooling to RT, the volatiles were removed in vacuo and the residue dissolved in DCM and washed with a saturated aqueous solution of NaHCO3. The aqueous phase was further extracted with DCM (×3) and the combined organic fractions were dried (Na2SO4) and concentrated in vacuo. The resulting residue was purified by column chromatography (Si—PCC, gradient 0-2% 2M NH3/MeOH in DCM) to afford the title compound (232 mg, 86%). The material was still impure and taken forward in the next step without further purification. LCMS (Method C): RT 3.54 min [M+H]+ 363.4

Provenance & Evidence