Trifluoroacetic acid → HCID 68158027, compound

Participants

Reaction Steps

To a solution of [(S)-1-(6-fluoro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]methylcarbamic acid tert-butyl ester (0.264 g, 0.72 mmol) in DCM (8 mL) was added TFA (4 mL) and the mixture stirred at RT for 1.5 h. The volatiles were removed under in vacuo and the resulting residue partitioned between DCM and a saturated aqueous solution of NaHCO3. The two phase system was stirred for 10 minutes and then the aqueous phase extracted with DCM. The combined organic fractions were dried (MgSO4) and concentrated in vacuo to afford the title compound as a colourless oil (102 mg, 53%). LCMS (Method J): RT 1.80 min [M+H]+ 270.2.

Provenance & Evidence