2,4-Difluoronitrobenzene → HCID 68157024, compound

Participants

Reaction Steps

A mixture of 2,4-difluoro-1-nitrobenzene (3.69 g, 23.2 mmol), 3-aminoazetidine-1-carboxylic acid tert-butyl ester (4.0 g, 23.2 mmol) and DIPEA (3.97 mL, 23.2 mmol) in CH3CN (37 mL) was stirred at RT for 18 h under an argon atmosphere. The volatiles were removed in vacuo and the resulting residue purified by column chromatography (Si—PCC, gradient 0-40% EtOAc in cyclohexane) to afford the title compound as a yellow solid (4.84 g, 67%). LCMS (Method B): RT 3.80 min [M+H]+ 312.1.

Provenance & Evidence