2-Aminopyridine → 3-Nitro-N-(pyridin-2-yl)pyridin-2-amine

Participants

Reaction Steps

2-Chloro-3-nitropyridine (3.42 g, 21.60 mmol) and pyridine-2-ylamine (6.09 g, 0.65 mol) in DMF (20 mL) were stirred together at 80° C. for 18 h. The reaction mixture was concentrated in vacuo and the residue purified by chromatography (SiO2 0-5% methanol in DCM) to give the title compound as an orange solid (1.68 g, 36%). LCMS (method H): Rt 1.45 min, [M+H]+ 217.

Provenance & Evidence