Hydrochloric Acid → 2-((S)-1-Aminoethyl)-5-fluoro-3-pyridin-2-yl-3H-benzoimidazole-4-carbonitrile dihydrochloride

Participants

Reaction Steps

[(S)-1-(7-Cyano-6-fluoro-1-pyridin-2-yl-1H-benzoimidazol-2-yl)ethyl]carbamic acid tert-butyl ester (563 mg, 1.47 mmol) was dissolved in hydrochloric acid in dioxane (10 mL, 4M) and the reaction stirred at RT for 1 h. The reaction mixture was concentrated in vacuo to yield the title compound as an off-white solid (523 mg, 100%). LCMS (Method C): RT=1.75 min, [M+H]+=282.

Provenance & Evidence