反应详情

A suspension of 2.1 g of 5-chlorosulfonyl-2-oxindole, 1.6 g of 4-trifluoromethylaniline and 1.4 g of pyridine in 20 mL of dichloromethane was stirred at room temperature for 4 hours. The precipitate which formed was collected by vacuum filtration, washed twice with 5 mL of water and dried under vacuum at 40° C. overnight to give 2.4 g of crude product containing some impurities by thin layer chromatography. The crude product was chromatographed on silica gel eluting with ethyl acetate:hexane (1:2) to give 1.2 g (37% yield) of 5-(4-trifluoromethylphenyl-aminosulfonyl)-2-oxindole.

1. customThe precipitate which formed
2. filtrationwas collected by vacuum filtration
3. washwashed twice with 5 mL of water
4. customdried under vacuum at 40° C. overnight
5. customto give 2.4 g of crude product
6. additioncontaining some impurities by thin layer chromatography
7. customThe crude product was chromatographed on silica gel eluting with ethyl acetate:hexane (1:2)