Trifluoroacetic acid → HCID 68157949, compound

Participants

Reaction Steps

{(S)-1-[6-Fluoro-1-(4-fluorophenyl)-1H-benzoimidazol-2-yl]ethyl}carbamic acid tert-butyl ester (0.8 g, 2.14 mmol) was dissolved in DCM (10 mL) and TFA (5 mL) added. The reaction mixture was stirred at RT for 1 h. The resultant mixture was concentrated in vacuo to afford a dark green gum. This was dissolved in DCM (40 mL) and stirred vigorously with saturated aqueous NaHCO3 (20 mL) for 10 minutes. The layers were separated and the organic fraction dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by column chromatography (silica gel, 10% MeOH in DCM) to afford the title compound (0.33 g, 57%). LCMS (Method C): RT 1.86 min [M+H]+ 274.2

Provenance & Evidence