HCID 68157734, compound → HCID 68158392, compound

Participants

Reaction Conditions

Reaction Steps

{(S)-1-[4-Fluoro-2-(2-fluorophenylamino)phenylcarbamoyl]ethyl}carbamic acid tert-butyl ester (0.7 g, 1.80 mmol) was dissolved in 4M HCl in dioxane (10 mL) and the reaction mixture was heated to 70° C. for 5 h. The resultant mixture was concentrated in vacuo and the residue dissolved in DCM (40 mL) and washed with saturated aqueous NaHCO3 (20 mL) and brine (20 mL). The organic fraction was dried (MgSO4), filtered and concentrated in vacuo to afford a red gum. This was purified by column chromatography (silica gel, gradient 0-10% MeOH in DCM) to afford the title compound (0.22 g, 46%). LCMS (Method C): RT 1.74 min [M+H]+ 274.3

Provenance & Evidence