HCID 68157885, compound → HCID 62377108, compound

Participants

Reaction Steps

(5-Fluoro-2-nitrophenyl)-(3-methoxyphenyl)amine (3.35 g, 12.7 mmol) was dissolved in EtOAc (50 mL) and the flask evacuated and flushed with nitrogen gas. 10% Pd/C (0.35 g) was added and the reaction mixture stirred under an atmosphere of hydrogen gas, at RT overnight. A further amount of 10% Pd/C (0.35 g) was added and the reaction mixture stirred under an atmosphere of hydrogen gas for a further 1 h. The resultant mixture was filtered through Celite® and the filtrate concentrated in vacuo to afford the title compound as a red gum (2.97 g, 100%). 1H NMR (CDCl3, 400 MHz): δ 7.15 (1H, t, J=8.08 Hz), 6.91 (1H, dd, J=9.89, 2.72 Hz), 6.76-6.62 (2H, m), 6.49-6.37 (3H, m), 5.29 (1H, s), 3.77 (3H, s), 3.52 (2H, s)

Provenance & Evidence