HCID 68156882, compound → HCID 68157528, compound

Participants

Reaction Steps

(5-Fluoro-2-nitrophenyl)pyrimidin-2-yl-amine (336 mg, 1.43 mmol) in IMS (25.0 ml) was added to palladium on charcoal (10 wt %, 35.0 mg) and stirred under a hydrogen atmosphere overnight. The mixture was filtered through Celite® and the filtrate concentrated in vacuo. The product was purified by chromatography (SiO2, 0-10% methanol/DCM) to yield the title compound (215 mg, 1.05 mmol, 74%). 1H NMR (MeOD, 400 MHz): δ 8.37 (2H, d, J=4.9 Hz), 7.29 (1H, dd, J 10.4, 2.9 Hz), 6.84 (1H, dd, J 8.8, 5.6 Hz), 6.77 (1H, t, J=4.9 Hz), 6.72 (1H, ddd, J 8.6, 8.1, 2.9 Hz).

Provenance & Evidence