HCID 68157994, compound → HCID 68157554, compound

Participants

Reaction Steps

A solution of (3-fluoro-6-nitro-2-pyridin-2-yl-phenyl)-(2-methoxyethyl)amine (414 mg, 1.4 mmol) in EtOAc (5 mL) was added to a slurry of palladium on carbon (10% by wt, 41 mg) in EtOAc (5 mL) under nitrogen. The reaction mixture was stirred at RT under an atmosphere of hydrogen for 4 h. The mixture was filtered through Celite® and the filtrate concentrated in vacuo to give the title compound as a yellow oil (382 mg, 99%). LCMS (Method C): RT 1.92 min [M+H]+ 262. 1H NMR (CDCl3, 400 MHz): δ 8.72 (1H, ddd, J=5.0, 2.0, 1.0 Hz), 7.77, (1H, ddd, J=8.0, 8.0, 2.0 Hz), 7.60-7.56 (1H, m), 7.26 (1H, ddd, J=7.5, 5.0, 1.0 Hz), 6.73-6.66 (2H, m), 5.67 (1H, bs), 3.86 (2H, bs), 3.18-3.16 (2H, m), 3.01 (3H, s), 2.96-2.93 (2H, m)

Provenance & Evidence