反应详情

温度

90 °C

A mixture of (S)-1-(6-fluoro-1-phenyl-1H-benzoimidazol-2-yl)propylamine (55 mg, 0.20 mmol), 6-chloro-9-(tetrahydropyran-2-yl)-9H-purine (49 mg, 0.20 mmol) and DIPEA (105 μL, 0.60 mmol) in IPA (0.5 mL) was heated for 24 h at 90° C. After cooling to RT, the volatiles were removed in vacuo and the resulting residue purified by column chromatography (Si—PPC, gradient 0-5% MeOH in DCM) to afford the title compound as a pale brown oil (84 mg, 89%). LCMS (Method J): RT=3.30 min, [M+H]+=471.

1. temperatureAfter cooling to RT
2. customthe volatiles were removed in vacuo
3. customthe resulting residue purified by column chromatography (Si—PPC, gradient 0-5% MeOH in DCM)