反应详情

TFA (40 mL) was added to a solution of [(S)-1-(7-bromo-6-fluoro-1-methyl-1H-benzoimidazol-2-yl)ethyl]carbamic acid tert-butyl ester (3.02 g, 8.11 mmol) in DCM (20 mL) and stirred for 15 minutes. The reaction mixture was concentrated in vacuo and the residue partitioned between DCM and saturated aqueous NaHCO3. The combined DCM extracts were dried (Na2SO4) and concentrated in vacuo to give the title compound as a white solid (2.04 g, 92%). LCMS (Method C): RT 1.83 min [M+H]+ 271.9, 273.9

1. concentrationThe reaction mixture was concentrated in vacuo
2. customthe residue partitioned between DCM and saturated aqueous NaHCO3
3. dry with materialThe combined DCM extracts were dried (Na2SO4)
4. concentrationconcentrated in vacuo