反应详情

TFA (10 mL) was added to a solution of {(S)-1-[6-fluoro-1-(1-methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]ethyl}carbamic acid tert-butyl ester (0.268 g, 0.75 mmol) in DCM (5 mL) and stirred for 15 minutes. The reaction mixture was concentrated in vacuo and the residue partitioned between DCM (×3) and saturated aqueous NaHCO3. The combined DCM extracts were dried (Na2SO4) and concentrated in vacuo. The resultant residue was purified by chromatography (SiO2, 0-10% (2M ammonia in methanol) in DCM) to give the title compound as an oil (0.113 g, 59%). LCMS (Method C): RT 1.72 min [M+H]+ 260.1

1. concentrationThe reaction mixture was concentrated in vacuo
2. customthe residue partitioned between DCM (×3) and saturated aqueous NaHCO3
3. dry with materialThe combined DCM extracts were dried (Na2SO4)
4. concentrationconcentrated in vacuo
5. customThe resultant residue was purified by chromatography (SiO2, 0-10% (2M ammonia in methanol) in DCM)