6-Fluoro-9-nitro-2,3-dihydro-1H-benzo[b]azepine → 6-Fluoro-2,3,4,5-tetrahydro-1H-benzo[B]azepin-9-amine

Participants

Reaction Steps

To a solution of 6-fluoro-9-nitro-2,3-dihydro-1H-benzo[b]azepine (225.4 mg, 1.0826 mmol) in EtOAc (15 mL) was added a slurry of 10% Pd/C (50 mg) in IMS (4 mL) and the reaction mixture was stirred at RT under a hydrogen atmosphere for 20 h. The suspension was then filtered through a pad of Celite® and the filtrate was concentrated in vacuo affording the title compound as a purple oil (197 mg, quantitative). LCMS (Method J): RT 1.69 min [M+H]+ 181\

Provenance & Evidence