Hydrochloric Acid → (S)-1-(6-Fluoro-7-methoxy-1-phenyl-1H-benzoimidazol-2-yl)ethylamine dihydrochloride

Participants

Reaction Steps

[(S)-1-(6-Fluoro-7-methoxy-1-phenyl-1H-benzoimidazol-2-yl)ethyl]carbamic acid tert-butyl ester (349 mg, 0.91 mmol) was dissolved in methanol (1 mL) and hydrochloric acid in dioxane (3 mL, 4M) and the reaction stirred at RT for 1 hour. The reaction mixture was concentrated in vacuo to yield the title compound as an off-white solid (321 mg, 100%). LCMS (Method C): RT=2.02 min, [M+H]+=286.

Provenance & Evidence