HCID 68157042, compound → HCID 68157586, compound

Participants

Reaction Steps

(3-Fluoro-6-nitro-2-pyridin-2-yl-phenyl)isopropylamine (0.49 g, 1.79 mmol) was dissolved in EtOAc (10 mL). The flask was evacuated and purged with N2. Pd/C (10%) was added and the mixture was hydrogenated at atmospheric pressure under a H2 atmosphere. The mixture was stirred overnight. The flask was evacuated and purged with N2. The catalyst was removed by filtration and the filtrate was concentrated in vacuo and the resulting residue was purified by chromatography (Si—PPC, gradient 0-50% EtOAc/cyclohexane) to afford the title compound as a yellow oil (0.47 g, 99%). 1H NMR (CDCl3, 400 MHz): δ 8.71 (1H, ddd, J=6.6, 2.4, 1.3 Hz), 7.78 (1H, ddd, J=10.6, 10.2, 2.5 Hz), 7.57 (1H, ddt, J=10.6, 5.2, 1.4 Hz), 7.26 (1H, ddd, J=10.0, 6.6, 1.6 Hz), 6.76-6.66 (2H, m), 5.34 (1H, br s), 3.80 (2H, br s), 3.19 (1H, sept, J=8.5 Hz), 7.63 (6H, d, J=8.5 Hz)

Provenance & Evidence