HCID 68157886, compound → HCID 68186358, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl-(3-fluoro-6-nitro-2-pyridin-2-yl-phenyl)amine (1.00 g, 3.82 mmol) and 10% palladium on carbon (0.10 g) in ethyl acetate (15 mL) was stirred under an atmosphere of hydrogen at atmospheric pressure and 20° C. for 3 days. The catalyst was removed by filtration and the resultant solution was concentrated in vacuo. The residue was purified by silica gel chromatography eluting (Si—PPC, gradient 0-100% EtOAc/cyclohexane) to give the title compound as yellow oil (0.61 g, 69%). 1H NMR (CDCl3) δ: 8.71 (1H, ddd, J=6.6, 2.5, 1.3 Hz), 7.78 (1H, ddd, J=10.5, 10.1, 2.5 Hz), 7.58 (1H, ddt, J=10.6, 5.0, 1.4 Hz), 7.27 (1H, ddd, J=10.0, 6.5, 1.6 Hz), 6.76-6.66 (2H, m), 5.24 (1H, br s), 3.82 (2H, br s), 2.76 (2H, t, J=9.5 Hz), 0.82 (3H, t, J=9.5 Hz)

Provenance & Evidence