Trifluoroacetic acid → HCID 68158146, compound

Participants

Reaction Steps

{(S)-1-[1-(3-Cyanocyclobutyl)-6-fluoro-1H-benzoimidazol-2-yl]ethyl}carbamic acid tert-butyl ester (0.21 g, 0.586 mmol) was added to 20% TFA in DCM (7 mL) and the resultant solution stirred at 20° C. for 1 hour. The reaction mixture was concentrated in vacuo and the residue loaded onto an Isolute® SCX-2 cartridge which was washed with DCM and MeOH, then the product was eluted with 2M NH3/MeOH and concentrated in vacuo to give title compound as a colourless solid (0.076 g, 51%). LCMS (Method J): RT 1.52 min [M+H]+ 259

Provenance & Evidence