反应详情

A solution of 4-chloro-1-(1-phenyl-1H-benzoimidazol-2-ylmethyl)-1H-Pyrazolo[3,4-d]pyrimidin-6-ylamine (1.5 g, 4 mmol) and Pd/C (0.3 g) in MeOH was stirred with H2 40 psi at 50° C. overnight. The mixture was filtered, and the filtrate was concentrated in vacuo. The residue was purified by P-TLC to give 157 (200 mg, yield 15%) as white solid. LCMS (ESI), M+H+=340.14. 1HNMR (400 MHz, DMSO) δ 5.0374 (s, 2H), 5.597 (s, 2H), 7.015 (s, 1H), 7.152-7.211 (m, 5H), 7.309-7.327 (m, 3H), 7.746 (s, 2H), 8.567 (s, 1H)

1. filtrationThe mixture was filtered
2. concentrationthe filtrate was concentrated in vacuo
3. customThe residue was purified by P-TLC