HCID 68157522, compound → HCID 178498687, compound

Participants

Reaction Steps

A solution of 5-fluoro-3-phenyl-2-{(S)-1-[9-(tetrahydropyran-2-yl)-9H-purin-6-ylamino]ethyl}-3H-benzoimidazole-4-carboxylic acid methyl ester (50 mg, 0.097 mmol) in MeOH (2 mL) and 4N HCl in dioxane (0.5 ml) was stirred at RT for 30 min then the volatiles were removed under reduced pressure. The resulting residue was dissolved in a minimum amount of MeOH and EtOAc. A solid precipitated on standing and was collected by filtration to afford 197 (21 mg, 46%). LCMS (Method K): RT 3.28 min [M+H]+ 432.1. 1H NMR (DMSO-d6, 400 MHz): δ 12.65 (1H, s), 9.92 (1H, br s), 8.61 (1H, s), 8.50 (1H, s), 7.89 (1H, dd, J=8.90, 4.75 Hz), 7.59-7.48 (2H, m), 7.45-7.30 (3H, m), 7.25 (1H, dd, J=10.49, 8.90 Hz), 5.51-5.40 (1H, m), 3.09 (3H, s), 1.65 (3H, d, J=6.84 Hz)

Provenance & Evidence