HCID 68157046, compound → HCID 68157615, compound

Participants

Reaction Steps

A mixture of {(S)-1-[6-fluoro-1-(5-fluoropyridin-2-yl)-1H-benzoimidazol-2-yl]ethyl}carbamic acid tert-butyl ester (33 mg, 0.09 mmol) in DCM (1 mL) and TFA (0.5 mL) was stirred at RT for 2 h. The crude reaction mixture was loaded onto an Isolute® SCX-2 cartridge and washed with MeOH followed by 2M NH3/MeOH. The basic fractions were combined and concentrated in vacuo to afford (S)-1-[6-fluoro-1-(5-fluoropyridin-2-yl)-1H-benzoimidazol-2-yl]ethylamine as a yellow oil (19 mg, 79%). LCMS (Method C): RT 0.27 and 1.84 min [M+H]+ 275.2.

Provenance & Evidence