Hydrochloric Acid → HCID 178456068, compound

Participants

Reaction Steps

HCl (0.25 mL of a 4M solution in dioxane) was added to a solution of {(S)-1-[6-fluoro-1-(5-fluoropyridin-3-yl)-1H-benzoimidazol-2-yl]propyl}-[9-(tetrahydropyran-2-yl)-9H-purin-6-yl]amine (96 mg, 0.20 mmol) in MeOH (1 mL) and the reaction mixture stirred at RT for 10 min. The crude reaction mixture was passed through a 2 g Isolute® SCX-2 cartridge, eluting with 2M NH3/MeOH. The basic fraction was concentrated in vacuo to give 359 (76 mg, 94%) as a white solid. LCMS (Method K): RT 3.23 min [M+H]+ 407.1. 1H NMR (CD3OD, 400 MHz): δ 8.59 (1H, s), 8.51 (1H, s), 8.05 (1H, s), 8.03 (1H, br s), 7.95 (1H, d, J=8.4 Hz), 7.65 (1H, dd, J=8.8, 4.6 Hz), 7.07 (1H, ddd, J=9.7, 8.8, 2.6 Hz), 6.88 (1H, dd, J=8.6, 2.6 Hz), 5.54-5.42 (1H, m), 2.26 (1H, dqd, J=14.9, 7.5, 6.4 Hz), 2.12 (1H, dqd, J=14.9, 7.5, 6.4 Hz), 1.01 (3H, t, J=7.5 Hz)

Provenance & Evidence