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A mixture of 4-amino-6-{(S)-1-[1-(3-benzyloxycyclobutyl)-6-fluoro-1H-benzoimidazol-2-yl]ethylamino}pyrimidine-5-carbonitrile (0.05 g, 0.11 mmol) in DCM (3 mL) was cooled to 0° C. To this mixture was added boron tribromide (0.22 mL, 0.22 mmol) dropwise and the resultant mixture stirred at RT for 2 h. The reaction mixture was quenched with MeOH (2 mL) and concentrated in vacuo. The resulting yellow solid was purified by column chromatography (Si—PCC, gradient 0-10% MeOH in DCM) to afford 404 as an off-white glassy solid (50 mg, 99%). 1H NMR (DMSO-d6): δ 7.97-8.09 (3H, m), 7.74 (1H, dd, J=7.75, 4.8 Hz), 7.50 (2H, br s), 7.26-7.36 (1H, m), 5.67 (1H, qn, J=6.7 Hz), 4.70 (1H, qn, J=8.5 Hz), 3.96 (1H, m), 2.72-2.91 (2H, m), 2.55-2.72 (2H, m), 1.6 (3H, d, 7.2 Hz). LCMS (Method K): RT 2.36 min [M+H]+ 368

1. customThe reaction mixture was quenched with MeOH (2 mL)
2. concentrationconcentrated in vacuo
3. customThe resulting yellow solid was purified by column chromatography (Si—PCC, gradient 0-10% MeOH in DCM)