HCID 59442846, compound → HCID 23079692, compound

HRID 243554Notes

Reaction equation

HRID 243554 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH:15]2[O:20][CH2:19][CH2:18][N:17]([CH3:21])[CH2:16]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:21][N:17]1[CH2:18][CH2:19][O:20][CH:15]([CH2:14][N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH2:16]1

Participants

4

Reactant 1

HCID 59442846HCID 59442846, compound

Product 1

HCID 23079692HCID 23079692, compoundYield 98.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

2-((4-benzylpiperazin-1-yl)methyl)-4-methylmorpholine (346 mg) is dissolved in ethanol (10 ml). Palladium on carbon (100 mg) is added and the mixture is stirred for 5 hours at 50° C. under an atmosphere of hydrogen (50 psi). The catalyst is removed by filtration and the filtrate concentrated under reduced pressure to give 4-methyl-2-(piperazin-1-ylmethyl)morpholine (234 mg). m/z(+) 200 (M+H+).

Workup

  1. customThe catalyst is removed by filtration
  2. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-ce068508401d4b85b9355a5b7af4d9c4
Source dataset
uspto-grants-2014_02
Patent number
US08653262B2

Reaction notes

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