Sodium Hydroxide → HCID 59442828, compound

Participants

Reaction Steps

1 M NaOH (23 ml) is added to a solution of ethyl 4-(4-benzylpiperazin-1-yl)cyclohexanecarboxylate (2.56 g) in Methanol (30 ml). The mixture is stirred for 2 days and the solvent is removed under reduced pressure. The crude product is purified using reverse phase HPLC (Varian C18 Microsorb) eluting with a gradient of 10-100% acetonitrile in water containing 0.2% trifluoroacetic acid to give 4-(4-benzylpiperazin-1-yl)cyclohexanecarboxylic acid: (2.33 g). m/z(+) 303 (M+H+).

Provenance & Evidence