Hydrazine hydrate (1:1) → tert-butyl(2S,3S)-2-[(2-aminoethyl)amino]-3-methylpentanoate

Participants

Reaction Conditions

Reaction Steps

To a solution of Example 32B (12.9 g) in ethanol (400 mL) was added hydrazine hydrate (11.2 mL). The solution was then heated to 70° C. for 2 hrs. After cooling to 25° C., the resulting solid was dissolved in 1N NaOH solution (200 mL) and water (200 mL). The solution was then extracted with dichloromethane (3×200 mL), the organic extracts combined, dried and evaporated to provide 6.8 g of the title compound.

Provenance & Evidence