Chlorosulfonic acid → HCID 86598730, compound

HRID 243617Notes

Reaction equation

HRID 243617 reaction equation
[Cl:1][S:2]([OH:5])(=O)=[O:3].[Cl:6][C:7]1[CH:8]=[C:9]([OH:14])[C:10]([CH3:13])=[CH:11][CH:12]=1>ClCCl>[Cl:6][C:7]1[CH:8]=[C:9]([OH:14])[C:10]([CH3:13])=[CH:11][C:12]=1[S:2]([Cl:1])(=[O:5])=[O:3]

Participants

4

Reactant 2

HCID 24638Chlorosulfonic acidHCID 791925-Chloro-o-cresol

Product 1

HCID 86598730HCID 86598730, compoundYield 2.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of chlorosulfonic acid (3.69 g, 31.65 mmol) dissolved in 30 mL of dichloromethane was added 3-chloro-6-methylphenol (3.0 g, 21.1 mmol) dropwise. After 10 minutes, the reaction was quenched by pouring it into ice water. The reaction was extracted with dichloromethane, washed with brine, dried over MgSO4, filtered, and concentrated to give 120 mg (2.4%) of the title compound.

Workup

  1. customthe reaction was quenched
  2. additionby pouring it into ice water
  3. extractionThe reaction was extracted with dichloromethane
  4. washwashed with brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-ae671365cc7d4e44a224cc773a72df04
Source dataset
uspto-grants-2014_02
Patent number
US08653141B2

Reaction notes

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