HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → trans-(11-Aminomethyl-8-chloro-10,11-dihydro-dibenzo[b,f]oxepin-10-yl)-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | Tetrahydrofuran toluene | HCID 22635083 | — |
| Reactant | Trans-8-chloro-11-nitromethyl-10,11-dihydro-dibenzo[b,f]oxepine-10-carboxylic acid methyl ester | HCID 59800204 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | trans-(11-Aminomethyl-8-chloro-10,11-dihydro-dibenzo[b,f]oxepin-10-yl)-methanol | HCID 56652617 | — |
Reaction Steps
A solution of trans-8-Chloro-11-nitromethyl-10,11-dihydro-dibenzo[b,f]oxepine-10-carboxylic acid methyl ester (8) (5.0 g, 13.23 mmol) in dry THF (25 ml) is added at −15° C. to a mixture of THF (25 ml) and 3.5 M LAH suspension in THF/Toluene (16.4 ml, 57.5 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653280B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-884229bc3b9341bc9cdd35c805d79e02 |
| Source note | uspto-grants-2014_02 |