L-Tartaric acid → 1-(5-tert-butyl-3-(hydroxymethyl)-2-methoxyphenyl)-3-((1S,2R)-4-fluoro-1-hydroxy-2,3-dihydro-1H-indene-2-yl)urea

Participants

Reaction Steps

Using 2,2,2-trichloroethyl 5-tert-butyl-3-(hydroxymethyl)-2-methoxyphenylcarbamate (0.100 g, 0.260 mmol) and (1S,2R)-2-amino-4-fluoro-2,3-dihydro-1H-indene-1-ol.L-tartaric acid salt (0.091 g, 0.286 mmol), the same reaction as in Example 1 (5th Step) was carried out to obtain 0.034 g of the captioned compound (32% yield).

Provenance & Evidence