Ammonium Chloride → HCID 68107858, compound

Participants

Reaction Steps

To a solution of 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethanol (0.440 g, 1.43 mmol) in ethanol (4.7 mL) and water (2.3 mL), ammonium chloride (0.230 g, 4.30 mmol) and iron powder (0.240 g, 4.30 mmol) were added, and the resulting mixture was heated to reflux for 15 hours. The temperature of the reaction solution was returned to room temperature, the insoluble materials were filtered through a Celite pad. After evaporating the organic solvent under reduced pressure, the aqueous layer was extracted with ethyl acetate, and the organic layer was washed with saturated brine. The organic layer was dried over anhydrous sodium sulfate and filtered, and the solvent was evaporated under reduced pressure to obtain 0.397 g of the crude product containing the captioned compound.

Provenance & Evidence