HCID 68107665, compound → HCID 68107570, compound

Participants

Reaction Steps

To a solution of 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoro-N-methylethaneamine (0.413 g, 1.29 mmol) in methanol (12.0 mL), 10% palladium/activated charcoal (0.041 g) was added and the resulting mixture was stirred at room temperature under hydrogen atmosphere for 3 hours. After completion of the reaction, the insoluble materials were filtered through a Celite pad, and the solvent was evaporated under reduced pressure. The obtained residue was purified by column chromatography (amine coated silica gel, hexane/ethyl acetate=90/10-0/100) to obtain 0.215 g of the captioned compound (57% yield).

Provenance & Evidence