2-Aminoindane → 1-(5-tert-butyl-2-methoxy-3-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-(2,3-dihydro-1H-indene-2-yl)urea

Participants

Reaction Conditions

Reaction Steps

To a solution of 2,2,2-trichloroethyl 5-tert-butyl-2-methoxy-3-(2,2,2-trifluoro-1-hydroxyethyl)phenylcarbamate (0.150 g, 0.331 mmol) and 2-aminoindane (0.053 g, 0.398 mmol) in acetonitrile (1.0 mL), N,N-diisopropylethylamine (0.173 mL, 0.994 mmol) was added, and the mixture was stirred at 110° C. for 18 hours. The reaction mixture was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate/n-hexane=0/100-60/40) to obtain 0.133 g of the captioned compound (92% yield).

Provenance & Evidence