Potassium Cyanide → HCID 68107449, compound

Participants

Reaction Steps

To a mixed solution of 5-tert-butyl-1-(chloromethyl)-2-methoxy-3-nitrobenzene (1.93 g, 7.49 mmol) in dioxane (5.0 mL), ethanol (5.0 mL) and water (2.5 mL), potassium cyanide (0.980 g, 15.0 mmol) was added, and the mixture was stirred for 2 hours under reflux. After cooling the mixture to room temperature and evaporated under reduced pressure and water was added to the residue. The resultant was extracted with ethyl acetate and then dried over anhydrous sodium sulfate, evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate/n-hexane=0/100-30/70) to obtain 1.84 g of the captioned compound (99% yield).

Provenance & Evidence